Cyanoguanidine derivative and process for preparation thereof

C - Chemistry – Metallurgy – 07 – C

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260/314, 260/540

C07C 323/44 (2006.01) C07D 233/64 (2006.01)

Patent

CA 1274848

ABSTRACT OF THE DISCLOSURE A novel cyanoguanidine derivative represented by the following general formula (I): Image (I) (wherein X stands for a hydrogen atom, a chlorine atom or a bromine atom, and R stands for a lower alkyl group), is an effective precursor for the synthesis of N-cyano-N'-methyl- N"-(2-(5-methyl-4-imidazolylmethylthio)ethyl)guanidine (Cimetidine) which has an action of controlling secretion of gastric acid and is valuable as an agent for the remedy of a gastric ulcer. This cyanoguanidine derivative is prepared by reacting a methylvinylketone derivative with a mercaptoguanidine derivative or by reacting an amidinoketone derivative with a halogenating agent.

545734

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