Cyanoguanidines as cell proliferation inhibitors

Details Cyanoguanidines as cell proliferation inhibitors Cyanoguanidines as cell proliferation inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/75 (2006.01) A61K 31/44 (2006.01)

Patent

CA 2292877

The present invention relates to hitherto unknown compounds of formula (I) or their tautomeric forms, the attachment to the pyridine being in the 3- or 4- position, in which formula R1 stands for one or more substituents which can be the same or different and are selected from the group consisting of: hydrogen, halogen, trifluoromethyl, nitro, amino, cyano, carboxy, or alkyl, alkoxy, or alkoxycarbonyl, the C-content of which can be from 1 to 4; X stands for a straight or branched C9-C20 carbon chain, saturated or unsaturated or Q-Ar-R; in which formula Ar stands for phenyl, Q stands for a C5-C20 divalent hydrocarbon radical which can be straight, branched, saturated or unsaturated and R stands for hydrogen or for one or more substituents which can be the same or different and are selected from the group consisting of: hydroxy, amino, halogen, trifluoromethyl, cyano, nitro, carboxy, carbamoyl, or alkyl, alkoxy, alkylthio, alkylamino, or alkoxycarbonyl, the C-content of which can be from 1 to 4; and pharmaceutically acceptable, non-toxic salts and N-oxides thereof. The present compounds are of value in the human and veterinary practice.

L'invention concerne des composés jusque-là inconnus, de formule (I), leurs formes tautomères, leurs sels et leurs N-oxydes non toxiques pharmaceutiquement acceptables, dans lesquels le noyau pyridine se fixe en position 3 ou 4. Dans la formule (I), R¿1? représente un ou plusieurs substituants, identiques ou différents, choisis dans le groupe comprenant hydrogène, halogène, trifluorométhyle, nitro, amino, cyano, carboxy, alkyle, alcoxy ou alcoxycarbonyle, le nombre de C étant compris entre 1 et 4; X représente une chaîne carbonée C¿9?-C¿20? droite ou ramifiée, saturée ou insaturée, ou bien Q-Ar-R (où Ar représente phényle, Q représente un radical hydrocarboné divalent C¿5?-C¿20? pouvant être droit, ramifié, saturé ou insaturé, et R représente hydrogène ou bien un ou plusieurs substituants, identiques ou différents, choisis dans le groupe comprenant hydroxy, amino, halogène, trifluorométhyle, cyano, nitro, carboxy, carbamoyle, alkyle, alcoxy, alkylthio, alkylamino ou alcoxycarbonyle, le nombre de C étant compris entre 1 et 4). Ces composés sont intéressants en pratique médicale et vétérinaire.

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