Cyanomethyl derivatives as cysteine protease inhibitors

Details Cyanomethyl derivatives as cysteine protease inhibitors Cyanomethyl derivatives as cysteine protease inhibitors

C - Chemistry, Metallurgy

07

K

C07K 5/062 (2006.01) A61K 38/05 (2006.01) A61P 35/00 (2006.01) C07K 5/078 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2506114

The present invention is directed to cyanomethyl derivatives that are inhibitors of cysteine protease, in particular, cathepsins B, K, L, F, and S and are therefore useful in treating diseases mediated by these proteases. The present invention is directed to pharmaceutical compositions comprising these compounds and processes for preparing them.

La présente invention concerne des dérivés de cyanométhyle qui sont des inhibiteurs de la protéase à cystéine, notamment, des cathepsines B, K, L, F, et S et qui sont utilisés dans le traitement de maladies médiées par ces protéases. Cette invention a également pour objet des compositions pharmaceutiques renfermant des composés et leurs procédés de préparation.

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