Cyanophenyl derivative

Details Cyanophenyl derivative Cyanophenyl derivative

C - Chemistry, Metallurgy

07

D

C07D 213/74 (2006.01) A61K 31/415 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/54 (2006.01) A61K 31/55 (2006.01) C07D 213/84 (2006.01) C07D 213/85 (2006.01) C07D 215/38 (2006.01) C07D 233/88 (2006.01) C07D 241/08 (2006.01) C07D 243/06 (2006.01) C07D 243/08 (2006.01) C07D 295/18 (2006.01) C07D 295/192 (2006.01) C07D 295/205 (2006.01) C07D 295/215 (2006.01) C07D 295/22 (2006.01) C07D 295/26 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 4

Patent

CA 2345146

This application relates to a piperazino-substituted novel cyanophenyl derivative in which a substituted carbamoyl or substituted sulfamoyl group having an aryl, heterocyclic or the like group that may have a substituent group is bonded to one nitrogen atom on the piperazine ring. The compound of this application has an anti- androgen action and is useful in preventing or treating prostatic cancer, benign prostatic hyperplasia and the like diseases.

Dérivés de cyanophényle à substituants pipérazine, dans lesquels un groupe carbamoyle ou sulfamoyle substitué, porteur d'un groupe aryle ou hétérocyclique, ou analogue, éventuellement substitué, est lié à l'atome d'azote constituant le noyau pipérazine. Ces dérivés présentent des activités antiandrogènes et sont utilisés en conséquence pour la prévention ou le traitement du cancer de la prostate, d'hypertrophie prostatique et analogue.

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