C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/31 (2006.01) A61K 38/16 (2006.01) A61K 47/48 (2006.01) A61P 31/12 (2006.01) A61P 31/18 (2006.01) C07K 14/195 (2006.01) C12N 15/63 (2006.01)
Patent
CA 2507904
The present invention provides variants of cyanovirin-N and water-soluble polymer, in particular PEGylated conjugates thereof. The cyanovirin-N of the invention are particularly suited for site-selective covalent attachment of one or more water soluble polymers, to provide polymer conjugates of cyanovirin-N variants exhibiting antiviral activity.
La présente invention porte sur des variants de la cyanovirine N et sur ses conjugués polymères solubles dans l'eau. La cyanovirine N de l'invention est notamment appropriée à la fixation covalente sélective sur site d'un ou plusieurs polymères solubles dans l'eau de façon à produire des conjugués polymères des variants de la cyanovirine N présentant une activité antivirale.
Boyd Michael R.
Mori Toshiyuki
O'keefe Barry R.
Roberts Michael J.
Snell M. Elizabeth
Gowling Lafleur Henderson Llp
Nektar Therapeutics
Nektar Therapeutics Al Corporation
The Government Of The United States Of America As Represented By The Se Cretary Of The Department Of Health And
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