C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 61/39 (2006.01) C07C 57/00 (2006.01) C07C 59/00 (2006.01) C07C 61/40 (2006.01) C07C 62/38 (2006.01) C07D 203/18 (2006.01) C07D 205/04 (2006.01) C07D 205/08 (2006.01) C07D 263/04 (2006.01) C07D 263/30 (2006.01) C07D 295/18 (2006.01) C07D 317/72 (2006.01) C07D 451/02 (2006.01) C07D 493/08 (2006.01)
Patent
CA 2661401
Novel compounds are provided which are 11-beta-hydroxysteroid dehydrogenase type I inhibitors. 11-Beta-hydroxysteroid dehydrogenase type I inhibitors are useful in treating, preventing, or slowing the progression of diseases requiring 11-beta-hydroxysteroid dehydrogenase type I inhibitor therapy. These novel compounds have the structure (I) enantiomers, diastereomers, solvates, or salts thereof, wherein A, W, X and Z are defined herein.
La présente invention concerne des inhibiteurs de 11-bêta hydroxystéroïde déshydrogénase. Les inhibiteurs de 11-bêta hydroxystéroïde déshydrogénase de type I sont utiles dans le traitement, la prévention, ou le ralentissement de la progression de maladies nécessitant une thérapie à base d'inhibiteurs de 11-bêta hydroxystéroïde déshydrogénase. Ces nouveaux composés sont de formule (I) dans laquelle: A, W, X et Z sont tels que définis dans la description, et leurs énantiomères, diastéréisomères, solvates, ou sels.
Guo Zhiwei
Hanson Ronald L.
Patel Ramesh N.
Robl Jeffrey A.
Ye Xiang-Yang
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
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