C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/32 (2006.01) A61K 31/34 (2006.01) A61K 31/341 (2006.01) A61K 31/4439 (2006.01) A61P 33/00 (2006.01) C07D 307/68 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2435117
Compounds of general formula (I), wherein R1, R2, R3, Y, (X)o, (W)n, (V)m, Z and U are as defined in the specification, are inhibitors of cruzipain and other cysteine protease inhibitors and are useful as therapeutic agents, for example in Chagas' disease, or for validating therapeutic target compounds.
L'invention porte sur des composés de formule générale (I) dans laquelle: R?1¿, R?2¿, Y,(X)¿o?, (W)¿n?, (V)¿m?, Z et U sont définis dans la specification. Il s'agit d'inhibiteurs de la cruzipain et d'autres cysteine proteases utilisables comme agents thérapeutiques, par exemple de la maladie de Chagas, ou comme composés de validation de cibles thérapeutiques.
Amura Therapeutics Limited
Ridout & Maybee Llp
LandOfFree
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