Cyclic amide derivatives

Details Cyclic amide derivatives Cyclic amide derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/454 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2401711

Novel compounds represented by the following formula (I) that act as a ligand to sigma receptor/binding cite and a medicament comprising the same as an active ingredient: (see formula I) wherein X represents an alkyl group, an aryl group, a heterocyclic group or the like; Q represents a group represented by -CH2-, -CO-, -O-, -CH(OR7)- or the like wherein R7 represents a hydrogen atom, an alkyl group or the like; n represents an integer of from 0 to 5; R1 and R2 each represent a hydrogen atom, an alkyl group or the like; B represents either of the following groups: (see formula II) wherein R3, R4, R5, and R6 each represent a hydrogen atom, a halogen atom, an alkoxyl group or the like; m represents 1 or 2; and the ring of: (see formula III) represents an aromatic heterocyclic ring.

L'invention concerne de nouveaux composés, représentés par la formule générale (I), qui servent de ligands pour les sites de liaison des récepteurs sigma ; ainsi que des médicaments renfermant lesdits composés comme principe actif. Dans ladite formule (I), X représente alkyle, aryle, un groupe hétérocyclique ou analogue; Q désigne CH2-, -CO-, -O-, -CH(OR7)- (où R7 représente hydrogène, alkyle ou analogue), ou analogue; n désigne un entier compris entre 0 et 5; R1 et R2 représentent chacun hydrogène, alkyle ou analogue; et B désigne un groupe représenté par la formule générale (II) ou (III): (où R3, R4, R5 et R6 représentent chacun hydrogène, halogéno, alcoxy ou analogue ; m désigne 1 ou 2; et le cycle (IV) est un hétérocycle aromatique).

Affiliated with

Also associated with

Rating

Cyclic amide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Cyclic amide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic amide derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1423974