Cyclic amide derivatives as neurokinin a antagonists

Details Cyclic amide derivatives as neurokinin a antagonists Cyclic amide derivatives as neurokinin a antagonists

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/395 (2006.01) C07D 401/06 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/06 (2006.01) C07D 491/056 (2006.01)

Patent

CA 2176036

Compounds of formula (I) wherein Q1, Q2, Q3, and Q4 have any of the meanings given in the specification, their <u>N</u>-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula (I) and intermediates.

L'invention concerne des composés de la formule (I) dans laquelle Q?1¿, Q?2¿, Q?3¿ et Q?4¿ ont les notations données dans la description du brevet, des <u>N</u>-oxydes ainsi que des sels pharmacologiquement acceptables de ces composés, qui sont des antagonistes non peptidiques de la neurokinine A et sont utiles dans le traitement de l'asthme, etc. L'invention se rapporte également à des compositions pharmaceutiques contenant les composés de la formule (I) ainsi qu'à des procédés de préparation de ces composés et de leurs intermédiaires.

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