C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 263/58 (2006.01) A61K 31/445 (2006.01) A61P 25/00 (2006.01) A61P 25/16 (2006.01) C07D 413/12 (2006.01) C07D 413/14 (2006.01) C07D 498/04 (2006.01)
Patent
CA 2478945
The invention relates to compounds of formula (I), the pharmaceutically acceptable derivatives, salts, solvates, stereoisomers and mixtures thereof, where X, Y, Z, R1, R3, R4, R8, p, k, E, G, Z and Q have the meanings given in claim 1, which find application as excitatory amino-acid antagonists for the treatment of neurodegenerative diseases including cerebrovascular diseases, epilepsy, schizophrenia, Alzheimer's, Parkinson's or Huntington's diseases, cerebral ischaemias, infarcts or psychoses.
L'invention concerne des composés de formule (I) ainsi que leurs dérivés, sels, solvates, stéréoisomères pharmaceutiquement utilisables et des mélanges de ces derniers, formule dans laquelle X, Y, Z, R?1¿, R?3¿, R?4¿, R?8¿, p, k, E, G, Z et Q ont les significations indiquées dans la revendication 1, utilisés comme antagonistes des acides aminés excitateurs dans la lutte contre les maladies neurodégénératives, y compris les maladies cérébrovasculaires, l'épilepsie, la schizophrénie, les maladies d'Alzheimer, de Parkinson et de Huntington, les ischémies cérébrales, les infarctus ou les psychoses.
Leibrock Joachim
Pruecher Helmut
Schadt Oliver
Seyfried Christoph
Fetherstonhaugh & Co.
Merck Patent Gesellschaft Mit Beschraenkter Haftung
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