C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 223/12 (2006.01) A61K 31/395 (2006.01) A61K 31/44 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 207/22 (2006.01) C07D 211/72 (2006.01) C07D 225/02 (2006.01) C07D 401/06 (2006.01) C07D 403/00 (2006.01) C07D 403/06 (2006.01) C07D 405/06 (2006.01) C07D 409/00 (2006.01) C07D 409/06 (2006.01) C07D 409/14 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 521/00 (2006.01) C07F 9/547 (2006.01)
Patent
CA 2216882
The current invention discloses amidino derivatives of formula (I) useful as nitric oxide synthase inhibitors wherein R1 is selected from the group consisting of cycloalkyl, heterocyclyl and aryl, which may optionally be substituted; L is selected from the group consisting of lower alkynylene, and (CH2)m-D-(CH2)n-; D is selected from the group consisting of O, S, SO, SO2, SO2NR7, NR7SO2, NR8, POOR7, PON(R7)2, POOR7NR7, NR7POOR7, C(O), C(O)O; B is selected from the group consisting of (CH2)v, CH=CH; A is selected from the group consisting of O, NR7, (CH2)q, CH=CH; X is selected from the group consisting of NH, O, S, (CH2)p and CH=CH.
L'invention concerne des dérivés amidino utiles comme inhibiteurs de synthase de l'oxyde nitrique, de la formule (I), où R1 est choisi dans le groupe qui comprend cycloalkyle, hétérocyclyle et aryle, pouvant être éventuellement substitués; L est choisi dans le groupe qui comprend alkynylène inférieur, et (CH2)m-D-(CH2)n-; D est choisi dans le groupe qui comprend O, S, SO, SO2, SO2NR7, NR7SO2, NR8, POOR7, PON(R7)2, POOR7NR7, NR7POOR7, C(O), C(O)O; B est choisi dans le groupe qui comprend (CH2)v, CH=CH; A est choisi dans le groupe qui comprend O, NR7, (CH2)q, CH=CH; X est choisi dans le groupe qui comprend NH, O, S, (CH2)p, et CH=CH.
Bergmanis Arija A.
Fok Kam F.
Hagen Timothy J.
Hallinan E. Ann
Hansen Donald W. Jr.
G.d. Searle & Co.
Osler Hoskin & Harcourt Llp
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