Cyclic amidinylthiocarbapenem derivatives

Details Cyclic amidinylthiocarbapenem derivatives Cyclic amidinylthiocarbapenem derivatives

C - Chemistry, Metallurgy

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C07D 477/00 (2006.01) A61K 31/395 (2006.01) C07D 207/24 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 413/04 (2006.01) C07D 477/20 (2006.01)

Patent

CA 2020727

ABSTRACT OF THE DISCLOSURE A compound represented by formula (I): Image (I) wherein R1 represents a hydrogen atom or a methyl group; R2 and R3, which may be the same or different, each represents a hydrogen atom or a lower alkyl group; and R4 represents a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group, a di-lower alkylcarbamoyl group, or a carbonyl group substituted with a heterocyclic group selected from the group consisting of an aziridinyl group, an azetidinyl group, a pyrrolidinyl group, a piperidino group, a morpholino group, a thio- morpholino group, a piperazinyl group, and a 4-lower alkyl- 1-piperazinyl group, or a pharmaceutically acceptable salt or ester thereof. The compound of formula (I) and their salts or esters exhibit excellent antibacterial activity.

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