Cyclic amine compound

Details Cyclic amine compound Cyclic amine compound

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/407 (2006.01) A61K 31/4355 (2006.01) A61K 31/4365 (2006.01) A61K 31/437 (2006.01) A61K 31/55 (2006.01) A61P 25/00 (2006.01) A61P 25/18 (2006.01) A61P 25/22 (2006.01) A61P 25/24 (2006.01) C07D 487/04 (2006.01) C07D 491/048 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2562406

A cyclic amine compound represented by the following formula (1). It has potent adhesion inhibitory activity against an .alpha.2C receptor and is useful for the prevention or treatment of disorders attributable to the .alpha.2C receptor, e.g., diseases such as depression and anxiety. (Formula 1) (In the formula, X represents O, S, SO, SO2, NR2, etc.; R1 represents hydrogen, cyano, etc.; Ar1 and Ar2 each represents aryl, heteroaryl, etc.; ring B represents a benzene ring, etc.; n is an integer of 1 to 10; and p and q each is 1 or 2.)

Composé amine cyclique représenté par la formule (1) suivante. Il a une puissante activité d'inhibition de l'adhérence vis-à-vis d'un récepteur .alpha.2C et il est utile pour la prévention ou le traitement de troubles attribuables au récepteur .alpha.2C, par exemple de maladies telles que la dépression et l'anxiété. (Formule 1) (dans la formule, X représente O, S, SO, SO¿2?, NR?2¿, etc. ; R?1¿ représente un hydrogène, un cyano, etc. ; Ar?1¿ et Ar?2¿ représentent chacun un aryle, un hétéroaryle, etc. ; le noyau B représente un noyau benzénique, etc. ; n est un nombre entier valant 1 à 10 ; et p et q sont chacun 1 ou 2.)

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