Cyclic amine compounds

Details Cyclic amine compounds Cyclic amine compounds

C - Chemistry, Metallurgy

07

D

C07D 211/58 (2006.01) A61K 31/4439 (2006.01) A61K 31/4468 (2006.01) A61K 31/4545 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 211/62 (2006.01) C07D 213/38 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2461963

A cyclic amine compound represented by the general formula (1): (1) (wherein R1, R2, and R3 each independently represents hydrogen, alkoxy, etc.; W1 and W2 are the same or different and each represents nitrogen or CH; X represents oxygen, NR4, CONR4, or NR4CO; R4 represents hydrogen, alkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, etc.; and l, m, and n each is 0 or 1), a salt of the compound, or a hydrate of either. The compound inhibits cellular adhesion and/or cellular infiltration and is useful as an antasthmatic, antiallergic, antirheumatic, antiarteriosclerotic, antiphlogistic, or anti-Sjögren's syndrome agent, etc.

L'invention concerne un composé d'amine cyclique représenté par la formule générale (1), dans laquelle R1, R2 et R3 représentent indépendamment un hydrogène, un alcoxy, etc. ; W1 et W2 sont identiques ou différents et désignent chacun un azote ou CH ; X représente un oxygène, NR4, CONR4 ou NR4CO ; R4 désigne un hydrogène, un alkyle, un aryle, un hétéroaryle, un aralkyle, un hétéroaralkyle, etc. ; et l, m et n sont égaux chacun à 0 ou 1, ainsi qu'un sel du composé ou un hydrate de ceux-ci. Le composé inhibe une adhésion cellulaire et/ou une infiltration cellulaire et est utile comme agent anti-asthmatique, anti-allergique, anti-rheumatismal, anti-artériosclérotique, anti-phlogistique ou anti-syndrome de Sjörgen, etc.

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