Cyclic amine derivative having heteroaryl ring

Details Cyclic amine derivative having heteroaryl ring Cyclic amine derivative having heteroaryl ring

C - Chemistry, Metallurgy

07

D

C07D 401/06 (2006.01) A61K 31/454 (2006.01) A61P 7/02 (2006.01) A61P 9/10 (2006.01)

Patent

CA 2547472

A compound represented by the general formula (I): (I) (wherein R1 represents C1-6 alkyl, etc.; R2 represents hydrogen, C2-7 alkanoyl, C7-11 arylcarbonyl, the formula R4-(CH2)l-, etc.; R3 represents C6-10 aryl, etc.; X1, X2, X3, X4, and X5 each independently represents hydrogen, halogeno, etc.; and n is an integer of 0 to 2), a pharmacologically acceptable salt of the compound, or a prodrug of either. They have excellent platelet activation inhibitory activity, etc. and are useful as a preventive or therapeutic agent for thromboembolization diseases.

L'invention concerne un composé représenté par la formule générale (I). Dans cette formule R?1¿ représente un alkyle en C¿1-6?, etc.; R?2¿ représente un hydrogène, et alcanoyle en C¿2-1?, un arylcarbonyle en C¿7-11?, la formule R?4¿-(CH¿2?)¿1?-, etc.; R?3¿ représente un aryle en C¿6-10?, etc.; X?1¿, X?2¿, X?3¿, X?4¿ et X?5¿ représentent chacun de façon indépendante un hydrogène, un halogéno, etc. et n prend la valeur d'un nombre entier entre 0 et 2. L'invention concerne également un sel du composé acceptable sur la plan pharmacologique, ou un promédicament de celui-ci. Ces dérivés présentent une activité inhibitrice de l'activation plaquettaire excellente, etc. et sont utiles en tant qu'agents de prévention ou de traitement des maladies thromboemboliques.

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