Cyclic amine derivative or salt thereof

Details Cyclic amine derivative or salt thereof Cyclic amine derivative or salt thereof

C - Chemistry, Metallurgy

07

C

C07C 217/54 (2006.01)

Patent

CA 2580980

Provided are compounds which are an NMDA antagonist having a broad safety margin and are useful as a treating agent or a preventing agent for Alzheimer's disease, cerebrovascular dementia, Parkinson's disease, ischemic apoplexy, pain, etc. Concretely provided are an amine derivative or its salt characterized in that the amine- containing structure A therein bonds to a 2- or 3-cyclic condensed ring (e.g., indane, tetralone,4,5,6,7-- tetrahydrobenzothiophene, 4,5,6,7-tetrahydrobenzofuran, 7,8-dihydro-6H- indeno[4,5-- b]furan,2,3-dihydro-1H-cyclopenta[1]naphthalene) via X1(bond or lower alkylene); and an NMDA antagonist containing it as an active ingredient thereof.

Cette invention concerne un composé utile en tant qu'antagoniste du NMDA, possédant une large région de sécurité, qui est un agent thérapeutique de la maladie d'Alzheimer, de la démence vasculaire (agnosie vasculaire), de la maladie de Parkinson, de l'accident vasculaire cérébral ischémique et des douleurs, ou un agent préventif de ces pathologies. Le composé est un dérivé d'amine ou un sel de celui-ci, caractérisé par le fait qu'il comprend une structure contenant une amine (A) ainsi qu'un noyau condensé di- ou tricyclique (indane, tétralone, 4,5,6,7-tétrahydrobenzothiophène, 4,5,6,7-tétrahydrobenzofurane, 7,8-dihydro-6H-indéno[4,5-b]furane, 2,3-dihydro-1H-cyclopenta[a]naphtalène, etc.) lié à la structure (A) par l'intermédiaire de X1 (une liaison, un alkylène inférieur, etc.). L'antagoniste du NMDA contient le dérivé ou le sel en tant que principe actif.

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