C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/12 (2006.01) A61K 31/425 (2006.01) A61K 31/4523 (2006.01) A61P 29/00 (2006.01) C07D 207/48 (2006.01) C07D 211/96 (2006.01) C07D 215/58 (2006.01) C07D 217/22 (2006.01) C07D 401/12 (2006.01) C07D 405/14 (2006.01) C07D 409/12 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)
Patent
CA 2522084
Compounds of formula (I) are effective for treatment of pain and diseases, such as inflammation mediated diseases. The invention encompasses novel compounds, pharmaceutically acceptable derivatives thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving pain, inflammation mediated by Bradykinin. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes wherein q, t, R, Ra, Rb, Rc and R2 are as defined herein.
La présente invention a trait à des composés de formule (I) efficaces pour le traitement de la douleur et de maladies, tels que des maladies induites par l'inflammation. L'invention a également trait à de nouveaux composés, leurs dérivés pharmaceutiquement acceptables, des compositions pharmaceutiques et des procédés pour la prophylaxie et le traitement de maladies et d'autres maladies ou conditions impliquant la douleur, l'inflammation induites par la bradykinine. La présente invention a également trait à des procédés pour la fabrication de tels composés ainsi qu'à des intermédiaires utiles dans de tels procédés. Dans la formule (I),, t, R, R?a¿, R?b¿, R?c¿ et R?2¿ sont tels que définis dans la description.
Askew Ben
Chen Jian J.
D'amico Derin C.
Fotsch Christopher H.
Groneberg Robert D.
Amgen Inc.
Array Biopharma Inc.
Gowling Lafleur Henderson Llp
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