Cyclic amine derivatives and their uses

Details Cyclic amine derivatives and their uses Cyclic amine derivatives and their uses

C - Chemistry, Metallurgy

07

D

C07D 211/58 (2006.01) C07D 205/04 (2006.01) C07D 207/09 (2006.01) C07D 207/14 (2006.01) C07D 211/26 (2006.01) C07D 211/34 (2006.01) C07D 211/56 (2006.01) C07D 211/60 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2373607

This invention relates to novel arylalkyl cyclic amine derivatives. This invention also relates to chemokine receptor antagonists that are effective as therapeutic agents and/or preventive agents for diseases such as atherosclerosis, rheumatoid arthritis, transplant rejection, psoriasis, asthma, ulcerative colitis, glomerulonephritis, multiple sclerosis, pulmonary fibrosis, and myocarditis, in which tissue infiltration of blood monocytes and lymphocytes plays a major role in the initiation, progression or maintenance of the disease. Furthermore, chemokine receptor antagonists also inhibit the interaction of viruses, which attack blood monocytes and lymphocytes, through the use of a chemokine receptor. One such example is the HIV virus.

L'invention concerne de nouveaux dérivés d'amine cycliques arylalkyle, ainsi que des antagonistes vis-à-vis des récepteurs de chimiokine qui sont des agents thérapeutiques et/ou préventifs efficaces contre des maladies comme l'athérosclérose, la polyarthrite rhumatoïde, le rejet de transplantation, le psoriasis, l'asthme, la colite ulcéreuse, la glomérulonéphrite, la sclérose en plaques, la fibrose pulmonaire, et la myocardite, dans lesquelles l'infiltration des monocytes et des lymphocytes sanguins joue un rôle majeur pour le démarrage, la progression et le maintien pathologiques. Par ailleurs, les antagonistes vis-à-vis des récepteurs de chimiokine inhibent l'interaction des virus qui attaquent les monocytes et les lymphocytes sanguins, par le biais d'un récepteur de chimiokine. On peut illustrer ce processus en prenant l'exemple du VIH.

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