Cyclic amine derivatives and use thereof

Details Cyclic amine derivatives and use thereof Cyclic amine derivatives and use thereof

C - Chemistry, Metallurgy

07

D

C07D 271/06 (2006.01) A61K 31/4245 (2006.01) A61K 31/4439 (2006.01) A61P 9/04 (2006.01) A61P 13/12 (2006.01) A61P 19/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01) C07D 413/04 (2006.01) C07D 413/14 (2006.01)

Patent

CA 2367395

Sulfonamide derivatives having a matrix metalloprotease inhibiting effect, which are compounds represented by general formula (I), optical isomers of the same, pharmaceutically acceptable salts of both, or solvates of them: wherein R1 and R2 are each independently hydrogen, optionally substituted lower alkyl, or the like; R3 is optionally substituted aryl, optionally substituted heteroaryl, or the like; X is -CH=CH-, -O-, or -S-; and Y is NHOH, hydroxyl, or lower alkyloxy.

Dérivés de sulfonamide exerçant un effet d'inhibition de métalloprotéase de matrice et consistant en des composés représentés par la formule (I), leurs isomères optiques, des sels acceptables sur le plan pharmaceutique de ces composés et de ces isomères optiques, ou leurs solvates: dans laquelle R?1¿ et R?2¿ représentent chacun indépendamment hydrogène, alkyle inférieur éventuellement substitué, par exemple; R?3¿ représente aryle éventuellement substitué, hétéroaryle éventuellement substitué, par exemple; X représente -CH=CH-, -O- ou -S-; Y représente NHOH, hydroxyle ou alkyloxy inférieur.

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