Cyclic amine derivatives of substituted quinoxaline...

Details Cyclic amine derivatives of substituted quinoxaline... Cyclic amine derivatives of substituted quinoxaline...

C - Chemistry, Metallurgy

07

D

C07D 241/44 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/55 (2006.01) A61K 31/675 (2006.01) C07D 241/50 (2006.01) C07D 401/00 (2006.01) C07D 403/00 (2006.01) C07D 405/00 (2006.01) C07D 409/00 (2006.01) C07D 417/00 (2006.01) C07D 471/04 (2006.01) C07D 491/048 (2006.01) C07D 491/113 (2006.01) C07D 495/04 (2006.01) C07F 9/6509 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2220076

A novel series of substituted quinoxaline 2,3-diones useful as neuroprotective agents are taught. Novel intermediates, processes of preparation, and pharmaceutical compositions containing the compounds are also taught. The compounds are glutamate antagonists and are useful in the treatment of stroke, cerebral ischemia, or cerebral infarction resulting from thromboembolic or hemorrhagic stroke, cerebral vasospasms, hypoglycemia, cardiac arrest, status epilepticus, perinatal asphyxia, anoxia, seizure disorders, pain, Alzheimer's, Parkinson's, and Huntington's Diseases.

L'invention concerne une nouvelle série de quinoxaline 2,3-diones substituées utiles comme agents neuroprotecteurs. L'invention concerne également de nouveaux intermédiaires, de nouveaux procédés de préparation et de nouvelles compositions pharmaceutiques contenant ces composés. Les composés sont des antagonistes du glutamate et ils sont utiles pour le traitement des attaques cérébrales, des ischémies cérébrales, des infarctus cérébraux résultant de thromboembolies ou d'hémorragies cérébrales, des angiospasmes cérébraux, de l'hypoglycémie, des arrêts cardiaques, de l'épilepsie, de l'asphyxie périnatale, de l'anoxie, des spasmes, de la douleur et des maladie d'Alzheimer, de Parkinson et d'Huntington.

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