Cyclic amine derivatives, processes for their preparation,...

C - Chemistry – Metallurgy – 07 – D

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C07D 211/34 (2006.01) A61K 31/445 (2006.01) A61K 31/4465 (2006.01) A61P 25/00 (2006.01) A61P 25/22 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2524894

A compound of formula (I) wherein R represents a radical selected from i) ii) iii) iv) where the substituents R1, R2, R3, R4, R4, R7 and the indices m, n and p are as defined in the description; or pharmaceutically acceptable salts and solvates thereof; processes for their preparation to pharmaceutical compositions containing them and their use in the treatment of conditions mediated by tachykinins and/or by selective inhibition of serotonin reuptake transporter protein.

L'invention concerne un composé représenté par la formule (I), dans laquelle R représente un radical choisi parmi i), ii), iii) et iv). Dans ces formules, les substituants R1, R2, R3, R4, R5, R6 et R¿7? ainsi que les indices m, n et p sont tels que définis dans le descriptif. L'invention concerne également des sels ou des solvates pharmaceutiquement acceptables de ce composé, des procédés de préparation de compositions pharmaceutiques contenant ceux-ci, ainsi que leur utilisation pour le traitement d'états médiés par des tachykinines et/ou par l'inhibition sélective de la protéine transporteuse de recaptage de la sérotonine.

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