Cyclic amine modulators of chemokine receptor activity

Details Cyclic amine modulators of chemokine receptor activity Cyclic amine modulators of chemokine receptor activity

A - Human Necessities

61

K

A61K 31/445 (2006.01) A61K 31/4453 (2006.01) A61K 31/4468 (2006.01) A61K 31/45 (2006.01) A61K 31/451 (2006.01) A61K 31/4525 (2006.01) A61K 31/4535 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/498 (2006.01) A61K 31/517 (2006.01) A61K 31/535 (2006.01) A61K 31/5375 (2006.01) A61K 31/5377 (2006.01) A61K 31/538 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 31/18 (2006.01) A61P 37/04 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 211/

Patent

CA 2296314

The present invention is directed to cyclic amines of formula (I), (wherein R1, R2, R3, m and n are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-1, CCR-2, CCR-2A, CCR-2B, CCR-3, CCR- 4, CCR-5, CXCR-3, and/or CXCR-4.

La présente invention se rapporte à des amines cycliques représentées par la formule (I), dans laquelle R?1¿, R?2¿, R?3¿, m et n sont définis dans le descriptif de l'invention. Ces amines s'avèrent utiles en tant que modulateurs de l'activité des récepteurs de chimiokines, et notamment des récepteurs CCR-1, CCR-2, CCR2A, CCR-2B, CCR-3, CCR-4, CCR-5, CXCR-3 et/ou CXCR-4.

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