Cyclic amino acid derivatives as cell adhesion inhibitors

Details Cyclic amino acid derivatives as cell adhesion inhibitors Cyclic amino acid derivatives as cell adhesion inhibitors

A - Human Necessities

61

K

A61K 31/165 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/425 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 47/12 (2006.01) A61K 47/16 (2006.01) A61K 47/20 (2006.01) A61K 47/22 (2006.01) C07C 229/48 (2006.01) C07C 229/56 (2006.01) C07C 229/66 (2006.01) C07C 233/57 (2006.01) C07C 233/63 (2006.01) C07C 235/74 (2006.01) C07C 235/78 (2006.01) C07C 235/82 (2006.01) C07C 237/14 (2006.01) C07C 237/20 (2006.01) C07C 237/22 (2006.01) C07C 237/24 (2006.01) C07C 237/28 (2006.01) C07C 237/38 (

Patent

CA 2309338

Cyclic amino acid derivatives of Formula (I) are antagonists of VLA-4 and/or .alpha.4.beta.7, and as such are useful in the inhibition or prevention of cell adhesion and cell-adhesion mediated pathologies. These compounds may be formulated into pharmaceutical compositions and are suitable for use in the treatment of asthma, allergies, inflammation, multiple sclerosis, and other inflammatory and autoimmune disorders.

L'invention porte sur des dérivés d'acide aminé cycliques de la formule (I) qui sont des antagonistes de VLA-4 et/ou .alpha.¿4?.beta.¿7?, et qui sont utiles pour inhiber ou prévenir l'adhésion cellulaire et des pathologies induites par l'adhésion cellulaire. Ces composés peuvent être formulés dans des compositions pharmaceutiques et sont appropriés pour être utilisés dans le traitement de l'asthme, des allergies, des inflammations, de la sclérose en plaques et autres maladies inflammatoires et autoimmunes.

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