Cyclic amino acid derivatives useful as pharmaceutical agents

Details Cyclic amino acid derivatives useful as pharmaceutical agents Cyclic amino acid derivatives useful as pharmaceutical agents

C - Chemistry, Metallurgy

07

C

C07C 271/22 (2006.01) A61K 31/16 (2006.01) A61P 25/00 (2006.01) C07C 233/47 (2006.01) C07C 233/51 (2006.01) C07C 233/84 (2006.01)

Patent

CA 2409768

Pro-drug compounds of the formula (I) or (II) and compositions containing them are provided that when administered to humans or other mammals provide an increased duration of active compound in the plasma compared to compounds of corresponding structure in which labile groups are not present. In the above formulae n, P, Q, R1, R2; and R3; are as defined in the specification. The compounds may be used to treat a range of neurological conditions, e.g. epilepsy or pain.

L'invention concerne des composés de promédicaments représentés par la formule (I) ou (II) ainsi que des compositions contenant ceux-ci, qui, administrés à des êtres humains ou à d'autres mammifères, confèrent au composé actif une durée accrue dans le plasma par comparaison avec des composés de structure correspondante exempts de groupes labiles. Dans les formules, n, P, Q, R?1¿, R?2¿ et R?3¿ sont tels que définis dans la spécification. Ces composés peuvent servir à traiter diverses affections neurologiques, p. ex. l'épilepsie ou la douleur.

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