Cyclic aminomethylene bisphosphonate derivatives

C - Chemistry – Metallurgy – 07 – J

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C07J 43/00 (2006.01) A61K 31/675 (2006.01) C07F 9/547 (2006.01) C07F 9/6503 (2006.01) C07F 9/6509 (2006.01) C07J 51/00 (2006.01) C07J 73/00 (2006.01)

Patent

CA 2091829

HOE 92/S 017 Abstract of the Disclosure A compound represented by the formula (I) [Formula 1] Image (I) or the formula (II) Image ( II) wherein R denotes a hydrogen atom or a lower alkyl group; Y and Z may be the same or different and independently denote alkylene groups containing 2-5 carbon atoms in their alkylene chains which may be-substituted with a lower alkyl(s); X denotes a single bond or an alkylene group containing 1-10 carbon atoms in its alkylene chain which may be substituted with a lower alkyl(s); A-O- denotes a residue of a compound having an estrogenic activity and q denotes an integer of 1-3, and physiologically acceptable salts thereof. The above compounds (I) or (II) are useful as a bone resorption inhibitor and a therapeutic agent for bone diseases.

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