C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) A01K 67/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/46 (2006.01) A61K 48/00 (2006.01) C07K 16/40 (2006.01) C12N 9/16 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2463790
Human, rat and mouse cAMP phosphodiesterase isoforms (denoted PDE4D7s), as well as the DNA (RNA) encoding such polypeptides, are disclosed. Also disclosed are methods for utilizing such polypeptides in diagnostic assays for identifying mutations in nucleic acid sequences encoding the polypeptides of the present invention, for detecting altered levels of the polypeptide of the present invention as a means of detecting diseases and methods of screening potential modulators, especially inhibitors, of the novel PDE4D7s disclosed herein. Such as inhibitors can be used, for example, as a means of increasing cyclic AMP in neurons and thus treating neurological problems, such as long term memory loss, if not preventing such maladies entirely. Transgenic animals expressing polypeptides disclosed herein are also described.
L'invention concerne des isoformes phosphodiestérases d'adénosine 5' monophosphate cycliques (cAMP) (nommés PDE4D7), ainsi que l'ADN (ARN) codant ces polypeptides. L'invention concerne également des procédés destinés à utiliser ces polypeptides dans des méthodes diagnostiques afin d'identifier les mutations dans les séquences d'acide nucléique codant les polypeptides de cette invention et afin de détecter les niveaux altérés du polypeptide de l'invention en vue de détecter des maladies. L'invention concerne aussi des procédés de criblage de modulateurs potentiels, notamment des inhibiteurs, du nouveau PDE4D7 de l'invention. Ainsi, des inhibiteurs peuvent être utilisés, par exemple, afin d'augmenter l'AMP cyclique dans les neurones, ce qui permet de traiter les problèmes neurologiques, tels que des pertes de mémoire à long terme, voire d'empêcher complètement ces maladies. L'invention décrit enfin des animaux transgéniques exprimant les polypeptides de cette invention.
de Vivo Mike
Leonard Christopher
Unterbeck Axel
Wang Daguang
Xin Xiaonen
Johnson Ernest Peter
Memory Pharmaceuticals Corporation
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