Cyclic amp-specific phosphodiesterase inhibitors

Details Cyclic amp-specific phosphodiesterase inhibitors Cyclic amp-specific phosphodiesterase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/415 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2395196

Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

L'invention porte sur de nouveaux composés qui sont des inhibiteurs puissants et sélectifs de PDE4, ainsi que sur leurs procédés de fabrication. L'invention porte également sur l'utilisation de ces composés dans le traitement des maladies inflammatoires et autres maladies générant des taux élevés de cytokines, et sur les troubles du système nerveux central (CNS).

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