Cyclic amp-specific phosphodiesterase inhibitors

Details Cyclic amp-specific phosphodiesterase inhibitors Cyclic amp-specific phosphodiesterase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/34 (2006.01) A61K 31/402 (2006.01) A61P 29/00 (2006.01) C07D 401/04 (2006.01)

Patent

CA 2395543

Pyrrole compounds having structural formula (I) or (II) that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

L'invention concerne des composés de pyrrole représentés par la formule structurelle (I) ou (II). Ces composés sont des inhibiteurs puissants et sélectifs de PDE4. L'invention concerne également des méthodes de fabrication de ces composés. L'invention concerne en outre l'utilisation de ces composés dans le traitement des maladies inflammatoires et d'autres maladies associées à des taux élevés de cytokines, ainsi que dans les troubles du système nerveux central (SNC).

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