Cyclic amp-specific phosphodiesterase inhibitors

Details Cyclic amp-specific phosphodiesterase inhibitors Cyclic amp-specific phosphodiesterase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/41 (2006.01) C07D 207/00 (2006.01) C07D 257/00 (2006.01) C07D 273/00 (2006.01) C07D 413/04 (2006.01)

Patent

CA 2395663

Novel compounds that are potent and selective inhibitors of PDE4, as well as methods of making the same, are disclosed. Use of the compounds in the treatment of inflammatory diseases and other diseases involving elevated levels of cytokines, as well as central nervous system (CNS) disorders, also is disclosed.

La présente invention concerne des composés constituant de puissants inhibiteurs sélectifs de la PDE4. L'invention concerne également les procédés de fabrication de ces composés. L'invention concerne enfin l'utilisation de ces composés pour le traitement d'affections inflammatoires et d'autres affections à niveaux élevés de cytokines, mais aussi pour le traitement de troubles du système nerveux central.

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