Cyclic analogs of histatins

Details Cyclic analogs of histatins Cyclic analogs of histatins

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) C07K 7/06 (2006.01) C07K 7/64 (2006.01)

Patent

CA 2285673

Cyclic analogues of histatin H-5, having from about 15 - 20 amino acid units exhibiting substantial identity to histatin H-5, and having a cyclic portion of from - 16 of the amino acid units, have been found to exhibit enhanced bio-activity against a variety of different microorganisms. The cyclic structure is imparted by replacement of naturally occurring amino acids in histatin-5 sequences by, for example, by cysteine units, so as to cause cyclization through formation of disulfide bridges.

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