Cyclic angiotensin analogs

Details Cyclic angiotensin analogs Cyclic angiotensin analogs

C - Chemistry, Metallurgy

07

K

C07K 7/14 (2006.01) A61K 38/08 (2006.01) A61L 31/16 (2006.01)

Patent

CA 2660208

The invention relates to analogs of angiotensins, in particular to cyclised analogs having Ang(l-8) agonistic or antagonistic activity and to cyclised Ang(l-7) analogs with agonistic or antagonistic activity and displaying improved proteolytic resistance compared to their linear counterparts. Provided is a cyclic angiotensin peptide analog comprising a thioether-bridge linkage between the amino acids corresponding to positions Tyr4 and Pro7 in naturally occurring Angiotensin. Also provided is the use of analogs in therapy, for example hypertension.

La présente invention concerne des analogues d'angiotensines, en particulier des analogues cyclisés ayant une activité agoniste ou antagoniste Ang(l-8) et des analogues Ang(l-7) cyclisés présentant une activité agoniste ou antagoniste, et faisant preuve d'une résistance protéolytique améliorée par comparaison avec leurs équivalents linéaires. L'invention concerne un analogue peptidique d'angiotensine cyclique contenant une liaison par pont thioéther entre les acides aminés correspondant aux positions Tyr4 et Pro7 de l'angiotensine naturelle. L'invention concerne également l'utilisation d'analogues en thérapie, notamment pour l'hypertension.

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