Cyclic anticoagulant peptides

Details Cyclic anticoagulant peptides Cyclic anticoagulant peptides

C - Chemistry, Metallurgy

07

K

530/7.02, 167/10

C07K 7/08 (2006.01) C07K 7/06 (2006.01) C07K 14/815 (2006.01) C12N 15/15 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1328540

ABSTRACT This invention relates to novel cyclic peptides of the formula: Image which are useful anticoagulant agents. The synthetic pep- tides described competitively prevent the binding of fib- rinogen to the recognition site of thrombin in exerting their anticoagulant effect and, thereby, provide a scienti- fically interesting and therapeutically significant adjuct to anticoagulant therapy.

566915

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