C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/228, 167/233
C07D 207/16 (2006.01) A61K 31/445 (2006.01) C07D 211/46 (2006.01) C07D 211/58 (2006.01) C07D 211/60 (2006.01) C07D 211/62 (2006.01)
Patent
CA 2001256
ABSTRACT Cyclic azaaliphatic compounds with a nitroxy function of the general formula: Image (I) wherein n is 1 or 2, R is a hydrogen atom or an H-(C1-C8)-alkylene, hydroxy-(C1-C8)-alkylene, R1R2N-(C1-C8)-alkylene, R1R2N-(C1-C8)-alkylene-CO- , R1R2N-CO-NR3-(C1-C8)-alkylene or R1R2N-CO- radical, R1 is a hydrogen atom or a straight-chained or branched, saturated or unsaturated or cyclic alkyl radical con- taining up to 6 carbon atoms, R2 is a hydrogen atom or a straight-chained or branched, saturated or unsaturated or cyclic alkyl radical containing up to 6 carbon atoms or R2, together with a -(CH2)- group of the neigh- bouring (C1-C8)-alkyl radical and the nitrogen atom, can bridge a heteroaliphatic ring containing 2 to 6 carbon atoms, R3 is a hydrogen atom or a straight- chained or branched, saturated or unsaturated or cyclic alkyl radical containing up to 6 carbon atoms, A is a valency bond or an -NR4-CO- or -CO-NR4- radical, R4 is a hydrogen atom or a straight-chained or branched, saturated or unsaturated or cyclic alkyl radical containing up to 6 carbon atoms and B is a valency bond or a straight-chained or branched alkylene chain containing up to 8 carbon atoms, in which a -CH2- group can be replaced by a cycloalkylene radical containing 3 to 7 carbon atoms and/or the optically- active forms thereof and/or the physiologically compatible, pharmaceutically acceptable salts thereof bring about a reduction of the oxygen requirement of the heart, an increase of the blood flow and a lower- ing of the blood pressure, they also display a nit- rate-like action of especially long duration and may be used in the prophylaxis or treatment of heart and circulatory diseases, for example, angina pectoris.
Bartsch Wolfgang
Michel Helmut
Schultz Michael
Simon Herbert
Boehringer Mannheim Gmbh
Swabey Ogilvy Renault
LandOfFree
Cyclic azaaliphatic compounds with nitroxy function,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Cyclic azaaliphatic compounds with nitroxy function,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Cyclic azaaliphatic compounds with nitroxy function,... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1511323