C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/12 (2006.01) A61K 31/55 (2006.01) A61P 29/00 (2006.01) C07C 259/08 (2006.01) C07D 213/56 (2006.01) C07D 213/82 (2006.01) C07D 215/12 (2006.01) C07D 215/14 (2006.01) C07D 307/24 (2006.01) C07D 401/14 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/04 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2401870
The present application describes novel cyclic .beta.-amino acid derivatives of formula (I) or pharmaceutically acceptable salt forms thereof, wherein ring B is a 5-7 membered cyclic system containing from 0-2 heteroatoms selected from O, N, NRa, and S(O)p, and 0-1 carbonyl groups and the other variables are defined in the present specification, which are useful as metalloprotease and as TNF-.alpha. inhibitors.
L'invention concerne des dérivés cycliques d'acides .beta.-aminés de formule (I) ou des sels de ces composés acceptables sur le plan pharmaceutique, dans laquelle le cycle B est un système cyclique de 5 à 7 éléments contenant de 0 à 2 hétéroatomes choisis parmi les atomes O, N, ou groupes NR?a¿, et S(O)¿p?, et de 0 à 1 groupe carbonyle, les autres variables étant définies dans les spécifications. Ces composés sont utiles comme inhibiteurs de métalloprotéase et du TNF-.alpha..
Chen Linhua
Decicco Carl
Duan Jingwu
Lu Zhonghui
Maduskuie Thomas P. Jr.
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
LandOfFree
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