Cyclic boroproline compounds

Details Cyclic boroproline compounds Cyclic boroproline compounds

C - Chemistry, Metallurgy

07

F

C07F 5/02 (2006.01) A61K 31/69 (2006.01) C07F 5/04 (2006.01)

Patent

CA 2334155

Substantially pure preparations of cyclid boroProline compounds that bind, in cyclic or linear form, to CD26 are provided. Methods for using the cyclic compounds to stimulate the activation andlor proliferation of immune cells to achieve preselected normal in vivo levels of these cells also are provided. Evidence of the oral bioavailability and activity of a preferred cyclic compound, valine-prolineboronic acid (ValboroPro), also is provided.

L'invention se rapporte à des préparations sensiblement pures de composés cycliques de boroProline qui se lient, sous forme linéaire ou cyclique, à la protéine CD26. L'invention se rapporte également à des procédés d'utilisation de ces composés cycliques pour stimuler l'activation et/ou la prolifération de cellules immunes afin d'obtenir des taux in vivo normaux, présélectionnés, de ces cellules. L'invention se rapporte également à la biodisponibilité orale et à l'activité d'un composé cyclique préféré, l'acide valine-prolineboronique (ValboroPro).

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