C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 265/10 (2006.01) A61K 31/42 (2006.01) A61K 31/535 (2006.01) C07D 261/02 (2006.01) C07D 413/06 (2006.01) C07D 413/12 (2006.01)
Patent
CA 2333647
The present invention relates generally to cyclic carbamates and isoxazolidines of Formula (I) or their pharmaceutically acceptable salts thereof, which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, processes for preparing such compounds, and to methods of using these compounds for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.
Cette invention concerne essentiellement des isoxazolidines et des carbamates cycliques qui correspondent à la formule (I), ainsi que leurs sels acceptables sur le plan pharmaceutique. Ces composés sont utiles en qualité d'antagonistes du complexe récepteur fribrinogène IIb/IIIa de glycoprotéine de plaquettes. Cette invention concerne également des compositions pharmaceutiques contenant ces composés, des procédés de préparation de ces composés, ainsi que des procédés d'utilisation de ces composés qui permettent d'inhiber l'agrégation des plaquettes, lorsqu'ils sont utilisés comme thrombolitiques, et/ou de traiter les troubles thromboemboliques.
Confalone Pasquale N.
Jin Fuqiang
Bristol-Myers Squibb Pharma Company
Dimock Stratton Llp
Dupont Pharmaceuticals Company
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