Cyclic depsipeptide sulfonylation, sulfenylation and...

C - Chemistry – Metallurgy – 07 – K

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C07K 11/02 (2006.01) A61K 38/15 (2006.01) C07D 273/00 (2006.01) C07D 295/26 (2006.01) C07D 413/12 (2006.01) C07F 9/6527 (2006.01)

Patent

CA 2202751

A process is disclosed for the aromatic sulfonylation, sulfenylation, thiocyanisation and phosphorylation of cyclic depsipeptides with 6 to 24 ring atoms, composed of .alpha.-hydroxycarboxylic acids and .alpha.-aminoacids and containing at least one phenyl residue. The process is characterised in that said cyclic depsipeptides are reacted with sulfonylation, sulfenylation, thiocyanisation or phosphorylation reactives, if required in the presence of catalysts, auxiliary substances and/or diluents. Also disclosed are the new compounds so obtained and their use as endoparasiticides.

Un procédé sert à sulfonyler, sulfényler, thiocyaniser et phosphoryler aromatiquement des depsipeptides cycliques avec 6 à 24 atomes cycliques, constitués d'acides hydroxycarboxyliques .alpha. et d'acides aminés .alpha. et contenant au moins un résidu phényle. Le procédé se caractérise en ce que l'on fait réagir les depsipeptides cycliques avec des réactifs de sulfonylation, de sulfénylation, de thiocyanisation ou de phosphorylation, le cas échéant en présence de catalyseurs, de substances auxiliaires et/ou de diluants. L'invention concerne également les nouveaux composés ainsi obtenus et leur utilisation comme endoparasiticides.

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