Cyclic depsipeptide synthetase and gene thereof, and mass...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/52 (2006.01) C12N 1/15 (2006.01) C12N 9/00 (2006.01) C12P 21/00 (2006.01) C12P 21/04 (2006.01)

Patent

CA 2384122

The present invention provides an enzyme that synthesizes a cyclic depsipeptide, particularly the substance 1022, and a gene thereof. A cyclic depsipeptide synthetase according to the present invention comprises (a) an amino acid sequence of SEQ ID NO: 2 or (b) a modified amino acid sequence of the amino acid sequence of SEQ ID NO: 2 that have one or more modifications selected from a substitution, a deletion, an addition and an insertion and has cyclic depsipeptide synthetase activity. A cyclic depsipeptide synthetase gene according to the present invention comprises a nucleotide sequence encoding a cyclic depsipeptide synthetase. The present invention also provides a recombinant vector and a transformant for expressing the cyclic depsipeptide synthetase, and a mass production system for the cyclic depsipeptide. The present invention further provides a method for producing the cyclic depsipeptide synthetase.

L'invention concerne des enzymes assurant la synthèse des depsipeptides cycliques (en particulier une substance dénommée PF1022) et des gènes correspondant à ces depsipeptides. Les synthases en question comprennent: (a) la séquence d'acides aminés SEQ ID N0:2; ou (b) une séquence d'acides aminés dérivée de la séquence susmentionnée moyennant une ou plusieurs modifications qui peuvent être substitution, suppression, adjonction et insertion, cette séquence ayant une activité de synthase de depsipeptide. L'invention concerne en outre des gènes correspondant à ces synthases, qui renferment des séquences nucléotidiques codant les synthases considérées. L'invention concerne également un système de production de masse de depsipeptide cyclique, un procédé relatif à l'élaboration des synthases de depsipeptides cycliques, etc.

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