Cyclic diamine compound with condensed-ring groups

Details Cyclic diamine compound with condensed-ring groups Cyclic diamine compound with condensed-ring groups

C - Chemistry, Metallurgy

07

D

C07D 209/14 (2006.01) A61K 31/4184 (2006.01) A61K 31/423 (2006.01) A61K 31/496 (2006.01) A61K 31/517 (2006.01) A61K 31/551 (2006.01) A61P 9/10 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07D 209/42 (2006.01) C07D 215/12 (2006.01) C07D 235/12 (2006.01) C07D 235/14 (2006.01) C07D 239/74 (2006.01) C07D 243/06 (2006.01) C07D 243/08 (2006.01) C07D 263/56 (2006.01) C07D 263/62 (2006.01) C07D 277/64 (2006.01) C07D 295/08 (2006.01) C07D 295/096 (2006.01) C07D 307/8

Patent

CA 2451452

A cyclic diamine compound of formula (1): (see formula 1) wherein R1 and R2 are individually a hydrogen atom or a methoxy group, provided R1 is a methoxy group when R2 is a hydrogen atom, or a hydrogen atom when R2 is a methoxy group; A is an oxygen atom, a sulfur atom, CH=CH, CH=N or NR3, in which R3 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, aryl or aryl lower alkyl group; B is a nitrogen atom, CH or CR4, in which R4 is a hydrogen atom, or a lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, aryl or aryl lower alkyl group; m is 1 or 2; and n is a number of 1 to 5, an acid-addition salt thereof, or a hydrate thereof. The compound has inhibitory effects on cell adhesion and is useful for treatment of allergy, asthma, rheumatism, arteriosclerosis, and inflammation.

Composés de diamine cyclique représentés par la formule (1), leur sels d'apport acide ou leurs hydrates, et médicaments contenant ces composés, sels ou hydrates: (1) dans laquelle R?1¿ et R?2¿ représentent chacun hydrogène ou méthoxy, dans la mesure où, quand R?2¿ représente hydrogène, R?1¿ représente méthoxy, tandis que, quand R?2¿ représente méthoxy, R?1¿ représente hydrogène; A représente oxygène, soufre, CH=CH, CH=N, ou NR?3¿ (dans laquelle R?3¿ représente hydrogène, alkyle inférieur, hydroxyalkyle inférieur, alcoxy inférieur-alkyle inférieur, aryle ou arylalkyle inférieur); B représente azote, CH ou CR?4¿ (dans laquelle R?4¿ représente hydrogène, alkyle inférieur, hydroxyalkyle inférieur, alcoxy inférieur-alkyle inférieur, aryle ou arylalkyle); m est un nombre de 1 ou 2 et n est un nombre de 1 à 5. Ces composés, sels et hydrates exercent une activité d'inhibition contre l'adhérence cellulaire et sont utiles en tant que médicaments contre l'allergie, l'asthme, les maladies rhumatismales, l'arthériosclérose ou l'inflammation.

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