Cyclic diamine compounds and medicine containing the same

Details Cyclic diamine compounds and medicine containing the same Cyclic diamine compounds and medicine containing the same

C - Chemistry, Metallurgy

07

D

C07D 233/70 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/55 (2006.01) C07D 235/28 (2006.01) C07D 263/58 (2006.01) C07D 277/74 (2006.01) C07D 277/80 (2006.01) C07D 401/12 (2006.01) C07D 413/04 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 498/04 (2006.01) C07F 9/6509 (2006.01) C07F 9/653 (2006.01) C07F 9/6558 (2006.01)

Patent

CA 2290744

The present invention offers novel cyclic diamine compounds and a pharmaceutical composition containing the same. The present invention relates to a compound represented by the formula (I) or salt(s) or solvate(s) thereof. (see formula I) (In the formula, (see formula II) is an optionally substituted divalent residue of benzene, pyridine, cyclohexane or naphthalene or is a vinylene group where Ar is an optionally substituted aryl group; X is -NH-, oxygen atom or sulfur atom; Y is -NR1-, oxygen atom, sulfur atom, sulfoxide or sulfone; Z is a single bond or -NR2-; R1 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group; R2 is hydrogen atom, optionally substituted lower alkyl group, optionally substituted aryl group or optionally substituted silyl lower alkyl group; l is an integer of from 0 to 15; m is an integer of 2 or 3; and n is an integer of from 0 to 3). The compound of the present invention is useful as a pharmaceutical composition, particuarly as an inhibitor of acyl coenzyme A cholesterol acyltransferase (ACAT).

Cette invention se rapporte à des composés représentés par la formule (I) et à des sels ou solvates de ces composés, qui sont chacun utiles en particulier comme inhibiteurs d'acyl-coenzyme A cholestérol acyltransférase (ACAT). Dans cette formule, (a) représente un reste bivalent éventuellement substitué de benzène, de pyridine, de cyclohexane ou de naphtalène, ou vinylène; Ar représente aryle éventuellement substitué; X représente -NH- , oxygène ou soufre; Y représente -NR1-, oxygène, soufre, sulfoxyde ou sulfone; Z représente une liaison double ou -NR2-; R1 and R2 représentent chacun hydrogène, alkyle inférieur éventuellement substitué, aryle éventuellement substitué ou silylalkyle inférieur éventuellement substitué; l représente un nombre entier compris entre 0 et 15; m est égal à 2 ou à 3; et n représente un nombre entier compris entre 0 et 3.

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