Cyclic dipeptides and azetidinone compounds and their use in...

A - Human Necessities – 61 – K

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A61K 38/05 (2006.01) A61K 31/495 (2006.01) C07D 241/04 (2006.01) C07D 401/14 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 471/04 (2006.01) C07D 487/04 (2006.01) C07K 5/097 (2006.01)

Patent

CA 2320378

The present invention provides 4-substituted-2-azetidinone compounds, bicyclic 2-5-diketopiperazine compounds, and pharmaceutical compositions thereof that are potent, safe and effective neuroprotective agents. Due to their strong central nervous system (CNS) activity, the compounds can be used to enhance memory and to treat a variety of neurological disorders. The compounds are particularly useful for treating neurological disorders caused by, or associated with, CNS trauma.

L'invention concerne des composés de 4-substituée-2-azétidinone, des composés bicycliques de 2-5-dikétopipérazine et leurs compositions pharmaceutiques qui sont des agents neuroprotecteurs puissants, sans danger et efficaces. Etant donné leur activité puissante sur le système nerveux central (CNS), on peut utiliser ces composés afin d'améliorer la mémoire et de traiter une variété de maladies neurologiques. Ces composés sont particulièrement utiles pour traiter des maladies neurologiques provoquées par un traumatisme du système nerveux central ou associées à ce traumatisme.

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