Cyclic ether derivatives

Details Cyclic ether derivatives Cyclic ether derivatives

C - Chemistry, Metallurgy

07

D

167/231, 167/245

C07D 317/14 (2006.01) A61K 31/335 (2006.01) C07D 317/22 (2006.01) C07D 327/04 (2006.01) C07D 405/04 (2006.01)

Patent

CA 2006095

A B S T R A C T TITLE: CYCLIC ETHER DERIVATIVES The invention concerns a cyclic ether derivative of the formula I, Image I wherein Ar1 is optionally substituted phenyl or naphthyl; A1 is (1-6C)alkylene,(3-6C)alkenylene, (3-6C)alkynylene or cyclo- (3-6C)alkylene; Ar2 is optionally substituted phenylene,or a 6 membered heterocyclene moiety containing up to three nitrogen atoms; R1 and R2 together form a group of the formula -A2-X-A3- wherein each of A2 and A3 is (1-6C)a1kylene and X is oxy, thio, sulphinyl, sulphonyl or imino; and R3 is (6C)alkyl, (2-6C)alkenyl,(2-6C)alkynyl or substituted (1- 4C)alkyl or a pharmaceutica11y-acceptable salt thereof. The compounds of the invention are inhibitors of the enzyme 5-lipoxygenase.

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