Cyclic ether derivatives having an anti-shock activity or a...

C - Chemistry – Metallurgy – 07 – D

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C07D 405/12 (2006.01) C07D 307/20 (2006.01) C07D 309/10 (2006.01) C07D 313/04 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 1320200

ABSTRACT Compounds of formula (I): Image (I) [wherein: 1 is Z - 4; A and B are oxygen or sulfur; one of R1 and R2 represents a long chain alkyl, alkylcarbamoyl or aliphatic acyl group and the other of R1 and R2 represents a group of formula (III): Image (III) in which E represents a single bond, a bivalent heterocyclic group or a group or formula -CO-, -COO- or -CONR6-, where R6 is hydrogen or an imino-protecting group; m is 0 - 3; n is 0-10; q is 0 or 1; R4 is optionally protected hydroxy, mercapto group or carboxy; and Q is an amino or nitrogen-containing hetrocyclic group] are PAF antagonists which may be used to treat asthma, hypotension, inflammation and shock. They may be prepared by introducing the appropriate group R1 and/or R2 into a compound in which one or both or these groups is replaced by an active group.

541335

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