C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) C07K 16/40 (2006.01) C12N 5/10 (2006.01) C12N 5/12 (2006.01) C12N 9/16 (2006.01) C12Q 1/44 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2363537
The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesterase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
La présente invention a pour objet de nouvelles séquences nucléotidiques isolées et purifiées, codant la phosphodiestérase spécifique de cGMP et liant cGMP désignée par le sigle cGB-PDE. Sont également divulgués des méthodes et des matières pour la production recombinante de polypeptides cGB-PDE, ainsi que des méthodes pour identifier des composés modulant l'activité enzymatique de polypeptides cGB-PDE.
Beavo Joseph A.
Corbin Jackie D.
Ferguson Kenneth M.
Francis Sharron H.
Kadlecek Ann
Board Of Regents Of The University Of Washington
Icos Corporation
Ridout & Maybee Llp
The Board Of Regents Of The University Of Washington
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