C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/55 (2006.01) C07H 21/00 (2006.01) C07K 16/40 (2006.01) C12N 5/18 (2006.01) C12N 9/16 (2006.01)
Patent
CA 2141060
The present invention provides novel purified and isolated nucleotide sequences encoding the cGMP-binding, cGMP-specific phosphodiesrtrase designated cGB-PDE. Also provided by the invention are methods and materials for the recombinant production of cGB-PDE polypeptide products and methods for identifying compounds which modulate the enzymatic activity of cGB-PDE polypeptides.
La présente invention se rapporte à de nouvelles séquences de nucléotides purifiées et isolées codant la phosphodiestérase de fixation du monophosphate de guanosine cyclique, avec spécificité pour celui-ci, désignée cGB-PDE. La présente invention décrit également des procédés et des matériaux de production par recombinaison de polypeptides de phosphodiestérase dite cGB-PDE, ainsi que des procédés d'identification de composés modulant l'activité enzymatique de polypeptides de cGB-PDE.
Beavo Joseph A.
Corbin Jackie D.
Ferguson Kenneth M.
Francis Sharron H.
Kadlecek Ann
Icos Corporation
Smart & Biggar
The Board Of Regents Of The University Of Washington
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