Cyclic heptapeptide anti-inflammatory agent

Details Cyclic heptapeptide anti-inflammatory agent Cyclic heptapeptide anti-inflammatory agent

C - Chemistry, Metallurgy

12

N

C12N 1/20 (2006.01) A61K 38/12 (2006.01) C07K 7/64 (2006.01) C12P 21/04 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2181827

A cyclic heptapeptide anti-inflammatory agent, named cyclomarin-A is disclosed as in the figure. Cyclomarin-A is produced by a specific marine actinomycete. The cyclomarin- A producing bacterium is isolated from sediment located in marine estuaries in and around San Diego, California. Fermentation of the isolated bacterium in saltwater based media produces cyclomarin-A as a secondary by-product. The cyclomarin-A is useful as an anti-inflammatory agent.

L'invention concerne un heptapeptide cyclique utilisable comme agent anti-inflammatoire, appelé cyclomarine-A. La cyclomarine-A est produite par un actinomycète marin spécifique. La bactérie qui produit la cyclomarine-A est isolée du sédiment que l'on rencontre dans les estuaires marins et autour de San Diego, en Californie. La fermentation de la bactérie isolée dans un milieu à base d'eau de mer produit de la cyclomarine-A comme sous-produit secondaire. La cyclomarine-A peut s'utiliser comme agent anti-inflammatoire.

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