Cyclic hexapeptide compounds

Details Cyclic hexapeptide compounds Cyclic hexapeptide compounds

C - Chemistry, Metallurgy

07

K

C07K 7/54 (2006.01) A01N 37/18 (2006.01) A61K 38/12 (2006.01) C07K 7/56 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2061432

85/AOR47 18214 TITLE OF THE INVENTION CYCLIC HEXAPEPTIDE COMPOUNDS ABSTRACT OF THE INVENTION Compounds of the formula Image and 85/AOR47 -i- 18214 Image wherein R1 is hydrogen or hydroxyl; R2 is hydrogen; hydroxyl or methyl, R3 is hydrogen or hydroxyl; R4 is C5-C23 alkyl, C5-C23 alkenyl, aryl or substituted aryl; R5 is -CH2OH, -CH(CH3)OH, -CH(CH2CONH2)OH; R6 is -CH2OH or -CH(CH3)OH; R is -CH2OH or -CH(CH3)OH; provided that when R4 is -(CH2)8CH(CH3)CH2CH(CH3)C2H5, R5 is -CH2OH or -CH(CH3)OH. The compounds are useful as antimicrobial agents, especially as antifungal agents.

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