C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/56 (2006.01) A61K 38/15 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2400872
This invention relates to new polypeptide compound represented by the general formula (I) wherein R1, R2, R3, R4, R5 and R6 are as defined in the description or a salt thereof which has antimicrobial activities (especially, antifungal activities), inhibitory activity on .beta.-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for prophylactic and/or therapeutic treatment of infectious diseases including Pneumocystic carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.
L'invention porte: sur un nouveau polypeptide de formule générale (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿ et R?6¿ sont définis dans la description, ou un de ses sels, à activité microbicide (et en particulier antifongique), et à activité inhibitrice de la .beta.-1,3-glucan synthase, sur son procédé de préparation, sur une composition pharmaceutique le contenant, et sur des procédés de traitement prophylactique et/ou thérapeutique de maladies infectieuses dont les infections par le Pneumocystis carinii (par exemple la pneumonie à Pneumocystis carinii), chez l'homme ou l'animal.
Barrett David
Matsuda Hiroshi
Matsuda Keiji
Matsuya Takahiro
Mizuno Hiroaki
Astellas Pharma Inc.
Fujisawa Pharmaceutical Co. Ltd.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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