Cyclic hexapeptide somatostatin analogs

Details Cyclic hexapeptide somatostatin analogs Cyclic hexapeptide somatostatin analogs

C - Chemistry, Metallurgy

07

K

530/7.26, 167/10

C07K 7/64 (2006.01) C07K 14/655 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1268899

1741S/0700A 17032 TITLE OF THE INVENTION CYCLIC HEXAPEPTIDE SOMATOSTATIN ANALOGS ABSTRACT OF THE DISCLOSURE Somatostatin analogs are prepared wherein a cyclic hexapeptide contains a secondary amino acid which replaces seven of the ring amino acids of somatostatin. The cyclic hexapeptides are easier to synthesize, have a longer duration of activity, and many have a greater level of activity than somatostatin. The compounds have the properties of inhibiting the release of glucagon, growth hormone and insulin. Certain of the compounds also are capable of inhibiting the release of gastric acid secretions. The compounds are particularly useful in the treatment of acromegaly, diabetes, diabetic retinopathy and peptic ulcers. These cyclic hexapeptides are prepared by the solid phase method and/or solution synthesis.

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