Cyclic hexapeptides having antibiotic activity

Details Cyclic hexapeptides having antibiotic activity Cyclic hexapeptides having antibiotic activity

C - Chemistry, Metallurgy

07

K

C07K 7/56 (2006.01) A61K 38/12 (2006.01) A61P 31/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2202058

This invention relates to new polypeptide compounds repre-sented by formula (I), wherein R1 is as defined in the description and pharmaceutically acceptable salt thereof which have antimicro-bial activities (especially, antifungal activities), inhibitory activity on .beta.-1,3-glucan synthase, to process for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prophylactic and/or therapeutic treatment of infectious dis-eases including Pneumocystis carinii infection (e.g. Pneumocystis carinii pneumonia) in a human being or an animal.

L'invention porte sur de nouveaux composés de polypeptides représentés par la formule (I) dans laquelle R<1> est tel que défini dans la description, ainsi que sur leurs sels pharmacocompatibles qui présentent des activités antimicrobiennes (et spécialement antifongiques), des activités inhibitrices de la beta -1, 3-glucan synthase, sur leur procédé de préparation des préparations pharmaceutiques en contenant, et sur une méthode de traitement prophylactique et/ou thérapeutique de maladies infectieuses dont celles dues au Pneumocystis carinii (par exemple la pneumonie à Pneumocystis carinii) chez l'homme ou l'animal.

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